Multimedia smashed head on with design madness last night at midtown’s Showtime House at Cassa Hotel and Residences. Held in three different penthouses, this year’s house featured a set of designers unafraid to take a leap into the unknown.

Charged with designing a room inspired by a different Showtime series (Dexter, The C Word, Weeds, The Borgias, etc.), the designers could go any direction they wanted. In The Borgias Room, a sound display of haunting church bells mixed with a heartbeat to give the room ominous emotions. The small boxy white room had a video display, a neon cross, a Marcel Wanders chair that looked like it had devil horns, and a neon blue halo. David Schwarz of Hush Studios Inc. spearheaded the room.

“We packed all the themes of the show into this little room,” said Schwarz. “Stay in here for 10 minutes and then walk outside. This room is an all encompassing experience. It physically impacts you.”

It does. The body goes warm, and the eyes take a second to adjust when you leave. On another floor, the Californication bedroom from Space 4 Architecture isn’t a bedroom at all. Through a slanted black hallway lined with faux grass, you walk into a white room with raised letters splashed against a wall, a whiskey bottle on a glass table, a laptop and a small television in the corner. A mirrored floor reflected a hand-painted ceiling. The slanted room stands for the uncertainty of certain sexual encounters.

“When you go to a bar and meet someone you never knew before who you sleep with, you never know what your getting into, or in the morning, how to get out of it,” says Ulderico Micara, an architect with Space 4. “He is a sexual predator, crippled by writer’s block, and consumed by ephemeral passions. That is not a bad thing.”

The Showtime House is located at Cassa Hotel and Residences at 70 West 45th Street. It will be open to the public on Saturdays from September 11 through October 24. Tickets cost $15 each, with all proceeds benefiting the nonprofit Harlem Children's Zone.