Anna Kendrick has the sneaking suspicion that her life is about to change. She’s onto something. The 24-year-old actress will star opposite George Clooney in Up in the Air, Jason Reitman’s adaptation of the best-selling Walter Kirn novel about a man obsessed with accruing frequent flier miles. “I’m allowing myself to think about the possibility that this could be a big deal, because I think the worst thing would be to get caught off guard,” says Kendrick, best known for playing Jessica, the fickle friend to Kristen Stewart’s Bella in Twilight. (She will reprise the role in this fall’s ravenously anticipated sequel, New Moon.)

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